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1.
Sensors (Basel) ; 24(3)2024 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-38339618

RESUMEN

Reconfigurable intelligent surfaces (RIS) offer the potential to customize the radio propagation environment for wireless networks, and will be a key element for 6G communications. However, due to the unique constraints in these systems, the optimization problems associated to RIS configuration are challenging to solve. This paper illustrates a new approach to the RIS configuration problem, based on the use of artificial intelligence (AI) and deep learning (DL) algorithms. Concretely, a custom convolutional neural network (CNN) intended for edge computing is presented, and implementations on different representative edge devices are compared, including the use of commercial AI-oriented devices and a field-programmable gate array (FPGA) platform. This FPGA option provides the best performance, with ×20 performance increase over the closest FP32, GPU-accelerated option, and almost ×3 performance advantage when compared with the INT8-quantized, TPU-accelerated implementation. More noticeably, this is achieved even when high-level synthesis (HLS) tools are used and no custom accelerators are developed. At the same time, the inherent reconfigurability of FPGAs opens a new field for their use as enabler hardware in RIS applications.

2.
Front Plant Sci ; 14: 1241576, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37881610

RESUMEN

Introduction: Intelligent monitoring systems must be put in place to practice precision agriculture. In this context, computer vision and artificial intelligence techniques can be applied to monitor and prevent pests, such as that of the olive fly. These techniques are a tool to discover patterns and abnormalities in the data, which helps the early detection of pests and the prompt administration of corrective measures. However, there are significant challenges due to the lack of data to apply state of the art Deep Learning techniques. Methods: This article examines the detection and classification of the olive fly using the Random Forest and Support Vector Machine algorithms, as well as their application in an electronic trap version based on a Raspberry Pi B+ board. Results: The combination of the two methods is suggested to increase the accuracy of the classification results while working with a small training data set. Combining both techniques for olive fly detection yields an accuracy of 89.1%, which increases to 94.5% for SVM and 91.9% for RF when comparing all fly species to other insects. Discussion: This research results reports a successful implementation of ML in an electronic trap system for olive fly detection, providing valuable insights and benefits. The opportunities of using small IoT devices for image classification opens new possibilities, emphasizing the significance of ML in optimizing resource usage and enhancing privacy protection. As the system grows by increasing the number of electronic traps, more data will be available. Therefore, it holds the potential to further enhance accuracy by learning from multiple trap systems, making it a promising tool for effective and sustainable fly population management.

3.
IEEE Trans Neural Netw Learn Syst ; 34(12): 10408-10418, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35452392

RESUMEN

Edge artificial intelligence (AI) is receiving a tremendous amount of interest from the machine learning community due to the ever-increasing popularization of the Internet of Things (IoT). Unfortunately, the incorporation of AI characteristics to edge computing devices presents the drawbacks of being power and area hungry for typical deep learning techniques such as convolutional neural networks (CNNs). In this work, we propose a power-and-area efficient architecture based on the exploitation of the correlation phenomenon in stochastic computing (SC) systems. The proposed architecture solves the challenges that a CNN implementation with SC (SC-CNN) may present, such as the high resources used in binary-to-stochastic conversion, the inaccuracy produced by undesired correlation between signals, and the complexity of the stochastic maximum function implementation. To prove that our architecture meets the requirements of edge intelligence realization, we embed a fully parallel CNN in a single field-programmable gate array (FPGA) chip. The results obtained showed a better performance than traditional binary logic and other SC implementations. In addition, we performed a full VLSI synthesis of the proposed design, showing that it presents better overall characteristics than other recently published VLSI architectures.

4.
Med. clín (Ed. impr.) ; 157(5): 226-233, septiembre 2021. graf, tab
Artículo en Español | IBECS | ID: ibc-215466

RESUMEN

Antecedentes y objetivo: El SARS-CoV-2 ha supuesto un importante reto de salud pública. Desde el inicio de la pandemia, se han postulado diferentes comorbilidades que se han asociado con espectros de mayor gravedad y mortalidad. Los objetivos de la presente investigación son: 1) analizar los factores asociados a la infección por SARS-CoV-2 (COVID-19) en un área sanitaria del norte de España; 2) conocer el posible papel de la vacunación antigripal y antineumocócica en el desarrollo de la COVID-19.Materiales y métodosSe ha realizado un estudio de casos y controles de test negativo. Se tuvieron en cuenta variables relacionadas con los antecedentes personales y vacunales. A pesar de que la definición epidemiológica de caso fue variando a lo largo del tiempo, se tuvo como referencia la correspondiente al 31 de enero del 2020 en España. Se efectuó un análisis bivariante y multivariante.ResultadosLa muestra incluyó a 188 pacientes, de los cuales 63 fueron casos y 125 controles. Los resultados muestran que la obesidad aumenta 2,4 veces el riesgo de padecer esta infección (IC 95% 1.301 a 4.521) y los antagonistas de los receptores de la angiotensina II (ARA-2) lo aumentan 2,2 veces (IC 95% 1.256 a 6.982). Por otro lado, la vacunación antineumocócica conjugada de 13 serotipos mostró resultados cercanos a la significación estadística (OR = 0,4; IC 95% 0,170 a 1.006).ConclusionesLa obesidad y el uso de fármacos ARA-2 aumentan el riesgo de la COVID-19. El conocimiento científico sobre los factores asociados a la COVID-19 debe seguir ampliándose. La presente investigación plantea la necesidad de profundizar en el papel de las vacunas sobre esta infección y sus posibles propiedades heterólogas. (AU)


Background and objective: SARS-CoV-2 has been and is a major global Public Health challenge. Since the beginning of the pandemic, different comorbidities have been postulated and associated with spectra of increased severity and mortality. The objectives of this research are: 1) to analyse the factors associated with SARS-CoV-2 infection (COVID-19) in a health area in northern Spain; 2) to understand the possible role of influenza vaccination and pneumococcal vaccination in the development of COVID-19.Materials and methodA test-negative case-control study was conducted. Variables related to personal and vaccination history were considered. Although the epidemiological definition of the case varied over time, the reference definition was that corresponding to 31/01/2020 in Spain. A bivariate and multivariate analysis was performed.ResultsThe sample included 188 patients, of which 63 were cases and 125 controls. The results show that obesity increases the risk 2.4-fold of suffering this infection (IC 95% 1,301-4,521) and ARA-2 increases it 2.2-fold (95% CI 1,256-6,982). On the other hand, anti-pneumococcal vaccination of 13 serotypes showed results close to statistical significance (OR = 0.4; 95% CI 0.170-1,006).ConclusionObesity and the use of ARA-2 increases the risk of COVID-19. Scientific knowledge about factors associated with COVID-19 should be expanded. The authors consider that the present research raises the need further investigate the role of vaccines in this infection and their possible heterologous properties. (AU)


Asunto(s)
Humanos , Coronavirus Relacionado al Síndrome Respiratorio Agudo Severo , Infecciones por Coronavirus/epidemiología , Factores de Riesgo , Vacunas , Preparaciones Farmacéuticas , Pandemias
5.
Med Clin (Engl Ed) ; 157(5): 226-233, 2021 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-34395910

RESUMEN

BACKGROUND AND OBJECTIVE: SARS-CoV-2 has been and is a major global Public Health challenge. Since the beginning of the pandemic, different comorbidities have been postulated and associated with spectra of increased severity and mortality. The objectives of this research are: 1) to analyse the factors associated with SARS-CoV-2 infection (COVID-19) in a health area in northern Spain; 2) to understand the possible role of influenza vaccination and pneumococcal vaccination in the development of COVID-19. MATERIALS AND METHOD: A test-negative case-control study was conducted. Variables related to personal and vaccination history were considered. Although the epidemiological definition of the case varied over time, the reference definition was that corresponding to 31/01/2020 in Spain. A bivariate and multivariate analysis was performed. RESULTS: The sample included 188 patients, of which 63 were cases and 125 controls. The results show that obesity increases the risk 2.4-fold of suffering this infection (IC 95% 1,301-4,521) and ARA-2 increases it 2.2-fold (95% CI 1,256-6,982). On the other hand, anti-pneumococcal vaccination of 13 serotypes showed results close to statistical significance (OR = 0.4; 95% CI 0.170-1,006). CONCLUSION: Obesity and the use of ARA-2 increases the risk of COVID-19. Scientific knowledge about factors associated with COVID-19 should be expanded. The authors consider that the present research raises the need further investigate the role of vaccines in this infection and their possible heterologous properties.


ANTECEDENTES Y OBJETIVO: El SARS-CoV-2 ha supuesto un importante reto de salud pública. Desde el inicio de la pandemia, se han postulado diferentes comorbilidades que se han asociado con espectros de mayor gravedad y mortalidad. Los objetivos de la presente investigación son: 1) analizar los factores asociados a la infección por SARS-CoV-2 (COVID-19) en un área sanitaria del norte de España; 2) conocer el posible papel de la vacunación antigripal y antineumocócica en el desarrollo de la COVID-19. MATERIALES Y MÉTODOS: Se ha realizado un estudio de casos y controles de test negativo. Se tuvieron en cuenta variables relacionadas con los antecedentes personales y vacunales. A pesar de que la definición epidemiológica de caso fue variando a lo largo del tiempo, se tuvo como referencia la correspondiente al 31 de enero del 2020 en España. Se efectuó un análisis bivariante y multivariante. RESULTADOS: La muestra incluyó a 188 pacientes, de los cuales 63 fueron casos y 125 controles. Los resultados muestran que la obesidad aumenta 2,4 veces el riesgo de padecer esta infección (IC 95% 1.301 a 4.521) y los antagonistas de los receptores de la angiotensina II (ARA-2) lo aumentan 2,2 veces (IC 95% 1.256 a 6.982). Por otro lado, la vacunación antineumocócica conjugada de 13 serotipos mostró resultados cercanos a la significación estadística (OR = 0,4; IC 95% 0,170 a 1.006). CONCLUSIONES: La obesidad y el uso de fármacos ARA-2 aumentan el riesgo de la COVID-19. El conocimiento científico sobre los factores asociados a la COVID-19 debe seguir ampliándose. La presente investigación plantea la necesidad de profundizar en el papel de las vacunas sobre esta infección y sus posibles propiedades heterólogas.

6.
Med Clin (Barc) ; 157(5): 226-233, 2021 09 10.
Artículo en Inglés, Español | MEDLINE | ID: mdl-33966881

RESUMEN

BACKGROUND AND OBJECTIVE: SARS-CoV-2 has been and is a major global Public Health challenge. Since the beginning of the pandemic, different comorbidities have been postulated and associated with spectra of increased severity and mortality. The objectives of this research are: 1) to analyse the factors associated with SARS-CoV-2 infection (COVID-19) in a health area in northern Spain; 2) to understand the possible role of influenza vaccination and pneumococcal vaccination in the development of COVID-19. MATERIALS AND METHOD: A test-negative case-control study was conducted. Variables related to personal and vaccination history were considered. Although the epidemiological definition of the case varied over time, the reference definition was that corresponding to 31/01/2020 in Spain. A bivariate and multivariate analysis was performed. RESULTS: The sample included 188 patients, of which 63 were cases and 125 controls. The results show that obesity increases the risk 2.4-fold of suffering this infection (IC 95% 1,301-4,521) and ARA-2 increases it 2.2-fold (95% CI 1,256-6,982). On the other hand, anti-pneumococcal vaccination of 13 serotypes showed results close to statistical significance (OR = 0.4; 95% CI 0.170-1,006). CONCLUSION: Obesity and the use of ARA-2 increases the risk of COVID-19. Scientific knowledge about factors associated with COVID-19 should be expanded. The authors consider that the present research raises the need further investigate the role of vaccines in this infection and their possible heterologous properties.


Asunto(s)
COVID-19 , SARS-CoV-2 , Estudios de Casos y Controles , Humanos , Pandemias , Vacunación
7.
Conserv Biol ; 35(1): 216-226, 2021 02.
Artículo en Inglés | MEDLINE | ID: mdl-32812277

RESUMEN

Invasive species have major impacts on biodiversity and are one of the primary causes of amphibian decline and extinction. Unlike other top ant invaders that negatively affect larger fauna via chemical defensive compounds, the Argentine ant (Linepithema humile) does not have a functional sting. Nonetheless, it deploys defensive compounds against competitors and adversaries. We estimated levels of ant aggression toward 3 native terrestrial amphibians by challenging juveniles in field ant trails and in lab ant foraging arenas. We measured the composition and quantities of toxin in L. humile by analyzing pygidial glands and whole-body contents. We examined the mechanisms of toxicity in juvenile amphibians by quantifying the toxin in amphibian tissues, searching for histological damages, and calculating toxic doses for each amphibian species. To determine the potential scope of the threat to amphibians, we used global databases to estimate the number, ranges, and conservation status of terrestrial amphibian species with ranges that overlap those of L. humile. Juvenile amphibians co-occurring spatially and temporally with L. humile die when they encounter L. humile on an ant trail. In the lab, when a juvenile amphibian came in contact with L. humile the ants reacted quickly to spray pygidial-gland venom onto the juveniles. Iridomyrmecin was the toxic compound in the spray. Following absorption, it accumulated in brain, kidney, and liver tissue. Toxic dose for amphibian was species dependent. Worldwide, an estimated 817 terrestrial amphibian species overlap in range with L. humile, and 6.2% of them are classified as threatened. Our findings highlight the high potential of L. humile venom to negatively affect amphibian juveniles and provide a basis for exploring the largely overlooked impacts this ant has in its wide invasive range.


Efectos del Veneno de la Hormiga Argentina sobre los Anfibios Terrestres Resumen Las especies invasoras tienen un impacto importante sobre la biodiversidad y son una de las causas principales del declive y extinción de los anfibios. A diferencia de otras hormigas super-invasoras que afectan negativamente a animales más grandes por medio de compuestos químicos de defensa, la hormiga argentina (Linepithema humile) no tiene unaguijón funcional. Sin embargo, esta hormiga despliega compuestos defensivos contra sus competidores y adversarios. Estimamos los niveles de agresión de las hormigas hacia tres anfibios terrestres nativos exponiendo a los anfibios juveniles en pistas de hormigas en el campo y en las arenas de forrajeo de las hormigas en el laboratorio. Medimos la composición y las cantidades de toxina que presenta L. humile por medio del análisis de las glándulas pigidiales y el contenido en el cuerpo completo. Examinamos los mecanismos de la toxicidad en los anfibios juveniles cuantificando la toxina en el tejido del anfibio, buscando daños histológicos y calculando las dosis tóxicas para cada especie de anfibio. Para determinar el alcance potencial de la amenaza para los anfibios usamos bases de datos mundiales para estimar el número, distribución y estado de conservación de las especies terrestres de anfibios con distribuciones que se solapan con la de L. humile. Los anfibios juveniles que co-ocurren temporal y espacialmente con L. humile mueren al encontrarse con esta especie de hormiga en sus pistas. En el laboratorio, cuando un anfibio juvenil entró en contacto con L. humile, las hormigas reaccionaron rápidamente rociando a estos juveniles con veneno proveniente de las glándulas pigidiales. La iridomyrmecina fue el compuesto tóxico que encontramos en las glándulas pigidiales. Después de ser absorbida por la piel del anfibio, se acumuló en el cerebro, los riñones y el hígado. La dosis tóxica para los anfibios depende de la especie. A nivel mundial, se estima que 817 especies de anfibios terrestres tienen una distribución que se solapa con la de L. humile, y el 6.2% de estas especies se encuentran clasificadas como amenazadas. Nuestros hallazgos resaltan el potencial alto del veneno de L. humile para tener efectos negativos sobre los anfibios juveniles y también proporcionan una base para la exploración de los impactos de esta hormiga en su amplio rango invasivo, los cuales generalmente son ignorados.


Asunto(s)
Venenos de Hormiga , Hormigas , Anfibios , Animales , Conducta Animal , Conservación de los Recursos Naturales
8.
Ann Otol Rhinol Laryngol ; 128(11): 1078-1080, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31204488

RESUMEN

OBJECTIVES: Inflammatory myofibroblastic tumor (IMT) is a rare benign lesion, especially in the pediatric age. There are several cases described in pulmonary, digestive and renal localizations, but involvement in head and neck area is infrequent. METHODS: Case report and review of the literature. RESULTS: A 1 year and 11 months old child, during 2 months had clinical signs of nasal respiratory insufficiency and epistaxis subsequently developing a purulent rhinorrhea and a sleep apnea. His pediatrician previously requested a sinus and cavum X-ray with the finding of an image compatible with an intranasal mass. Endoscopic resection was performed of the mass with further immunohistochemical analysis showing the result of a lesion compatible with IMT. CONCLUSIONS: Even though there are very few cases in scientific literature of a tumor with these characteristics in infants, IMT must be present as a differential diagnosis of intranasal masses. The role of the pathologist is essential to reach the definitive diagnosis and the performance of an early surgical treatment decreases aesthetic consequences in this pathology.


Asunto(s)
Endoscopía/métodos , Epistaxis/etiología , Cavidad Nasal/patología , Neoplasias de Tejido Muscular/diagnóstico , Neoplasias de los Senos Paranasales/diagnóstico , Senos Paranasales/diagnóstico por imagen , Diagnóstico Diferencial , Epistaxis/diagnóstico , Humanos , Lactante , Imagen por Resonancia Magnética , Masculino , Neoplasias de Tejido Muscular/complicaciones , Neoplasias de Tejido Muscular/cirugía , Neoplasias de los Senos Paranasales/complicaciones , Neoplasias de los Senos Paranasales/cirugía , Tomografía Computarizada por Rayos X
9.
Int J Neural Syst ; 29(8): 1950004, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30880526

RESUMEN

Spiking neural networks (SNN) are able to emulate real neural behavior with high confidence due to their bio-inspired nature. Many designs have been proposed for the implementation of SNN in hardware, although the realization of high-density and biologically-inspired SNN is currently a complex challenge of high scientific and technical interest. In this work, we propose a compact digital design for the implementation of high-volume SNN that considers the intrinsic stochastic processes present in biological neurons and enables high-density hardware implementation. The proposed stochastic SNN model (SSNN) is compared with previous SSNN models, achieving a higher processing speed. We also show how the proposed model can be scaled to high-volume neural networks trained by using back propagation and applied to a pattern classification task. The proposed model achieves better results compared with other recently-published SNN models configured with unsupervised STDP learning.


Asunto(s)
Potenciales de Acción , Computadores , Redes Neurales de la Computación , Procesos Estocásticos , Aprendizaje Automático , Reconocimiento de Normas Patrones Automatizadas
10.
PLoS One ; 13(5): e0197597, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29795611

RESUMEN

This work focuses on the experimental data analysis of electroencephalography (EEG) data, in which multiple sensors are recording oscillatory voltage time series. The EEG data analyzed in this manuscript has been acquired using a low-cost commercial headset, the Emotiv EPOC+. Our goal is to compare different techniques for the optimal estimation of collective rhythms from EEG data. To this end, a traditional method such as the principal component analysis (PCA) is compared to more recent approaches to extract a collective rhythm from phase-synchronized data. Here, we extend the work by Schwabedal and Kantz (PRL 116, 104101 (2016)) evaluating the performance of the Kosambi-Hilbert torsion (KHT) method to extract a collective rhythm from multivariate oscillatory time series and compare it to results obtained from PCA. The KHT method takes advantage of the singular value decomposition algorithm and accounts for possible phase lags among different time series and allows to focus the analysis on a specific spectral band, optimally amplifying the signal-to-noise ratio of a common rhythm. We evaluate the performance of these methods for two particular sets of data: EEG data recorded with closed eyes and EEG data recorded while observing a screen flickering at 15 Hz. We found an improvement in the signal-to-noise ratio of the collective signal for the KHT over the PCA, particularly when random temporal shifts are added to the channels.


Asunto(s)
Electroencefalografía/instrumentación , Electroencefalografía/normas , Relación Señal-Ruido , Algoritmos , Ondas Encefálicas , Electroencefalografía/métodos , Humanos , Análisis de Componente Principal , Procesamiento de Señales Asistido por Computador
11.
Eur Arch Otorhinolaryngol ; 275(7): 1827-1830, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29799083

RESUMEN

INTRODUCTION: Tracheoesophageal speech is considered the gold standard for rehabilitation following total laryngectomy. Current literature is limited and contradictory about the possible causes of device failure. The aim of the study is to compare the device life-time between the Provox 2 and Provox Vega and to examine possible related factors that influence their duration. METHODS: Retrospective case-crossover study in 34 laryngectomized patients who had undergone tracheoesophageal voice rehabilitation using indwelling Provox 2 and Provox Vega voice prostheses between 2010 and 2016 in a tertiary care centre. RESULTS: A total of 440 prostheses were evaluated. The most frequent reason for replacement was due to an endoprosthesis leakage (n = 221, 64.2%) in both models. Radiotherapy increases the risk of prosthesis replacement (IRR = 1.88, p = 0.007) as well as bilateral neck dissection (IRR = 1.56, p = 0.017) in Provox 2. Age and unilateral neck dissection do not seem to influence the duration of the prosthesis. Mean life-time of Provox 2 was 106.64 days and 124.19 days for Provox Vega (p = 0.261). Complementary treatment with radiotherapy demonstrated a lower device survival (p < 0.001). DISCUSSION: Results confirmed the non-significant differences on device life between Provox Vega and Provox 2, as well as the relevant role of radiotherapy treatment in the increase of replacements and diminution of the device duration.


Asunto(s)
Neoplasias Laríngeas/cirugía , Laringectomía , Laringe Artificial , Falla de Prótesis , Adulto , Anciano , Estudios Cruzados , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Diseño de Prótesis , Implantación de Prótesis , Estudios Retrospectivos
12.
Res Vet Sci ; 109: 129-134, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-27892861

RESUMEN

Myxomatosis and rabbit hemorrhagic disease (RHD) are the major viral diseases that affect the wild European rabbit (Oryctolagus cuniculus). These diseases arrived in Europe within the last decades and have caused wild rabbit populations to decline dramatically. Both viruses are currently considered to be endemic in the Iberian Peninsula; periodic outbreaks that strongly impact wild populations regularly occur. Myxoma virus (MV) and rabbit hemorrhagic disease virus (RHDV) alter the physiology of infected rabbits, resulting in physical deterioration. Consequently, the persistence and viability of natural populations are affected. The main goal of our study was to determine if blood biochemistry is correlated with serostatus in wild European rabbits. We carried out seven live-trapping sessions in three wild rabbit populations over a two-year period. Blood samples were collected to measure anti-MV and anti-RHDV antibody concentrations and to measure biochemical parameters related to organ function, protein metabolism, and nutritional status. Overall, we found no significant relationships between rabbit serostatus and biochemistry. Our main result was that rabbits that were seropositive for both MV and RHDV had low gamma glutamyltransferase concentrations. Given the robustness of our analyses, the lack of significant relationships may indicate that the biochemical parameters measured are poor proxies for serostatus. Another explanation is that wild rabbits might be producing attenuated physiological responses to these viruses because the latter are now enzootic in the study area.


Asunto(s)
Infecciones por Caliciviridae/veterinaria , Virus de la Enfermedad Hemorrágica del Conejo/fisiología , Myxoma virus/fisiología , Mixomatosis Infecciosa/epidemiología , Conejos , Animales , Análisis Químico de la Sangre/veterinaria , Infecciones por Caliciviridae/epidemiología , Infecciones por Caliciviridae/virología , Femenino , Masculino , Mixomatosis Infecciosa/virología , Prevalencia , Estudios Seroepidemiológicos , España/epidemiología
15.
Vet Res ; 45: 39, 2014 Apr 05.
Artículo en Inglés | MEDLINE | ID: mdl-24708296

RESUMEN

Host-pathogen epidemiological processes are often unclear due both to their complexity and over-simplistic approaches used to quantify them. We applied a multi-event capture-recapture procedure on two years of data from three rabbit populations to test hypotheses about the effects on survival of, and the dynamics of host immunity to, both myxoma virus and Rabbit Hemorrhagic Disease Virus (MV and RHDV). Although the populations shared the same climatic and management conditions, MV and RHDV dynamics varied greatly among them; MV and RHDV seroprevalences were positively related to density in one population, but RHDV seroprevalence was negatively related to density in another. In addition, (i) juvenile survival was most often negatively related to seropositivity, (ii) RHDV seropositives never had considerably higher survival, and (iii) seroconversion to seropositivity was more likely than the reverse. We suggest seropositivity affects survival depending on trade-offs among antibody protection, immunosuppression and virus lethality. Negative effects of seropositivity might be greater on juveniles due to their immature immune system. Also, while RHDV directly affects survival through the hemorrhagic syndrome, MV lack of direct lethal effects means that interactions influencing survival are likely to be more complex. Multi-event modeling allowed us to quantify patterns of host-pathogen dynamics otherwise difficult to discern. Such an approach offers a promising tool to shed light on causative mechanisms.


Asunto(s)
Infecciones por Caliciviridae/veterinaria , Virus de la Enfermedad Hemorrágica del Conejo/fisiología , Myxoma virus/fisiología , Mixomatosis Infecciosa/virología , Conejos , Factores de Edad , Animales , Anticuerpos Antivirales/sangre , Infecciones por Caliciviridae/epidemiología , Infecciones por Caliciviridae/virología , Ensayo de Inmunoadsorción Enzimática/veterinaria , Femenino , Interacciones Huésped-Patógeno , Masculino , Modelos Biológicos , Mixomatosis Infecciosa/epidemiología , Densidad de Población , Dinámica Poblacional , Prevalencia , Estaciones del Año , Estudios Seroepidemiológicos , Factores Sexuales , España/epidemiología
16.
J Wildl Dis ; 49(1): 10-7, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-23307367

RESUMEN

The interaction among several parasites in European rabbits (Oryctolagus cuniculus) is crucial to host fitness and to the epidemiology of myxomatosis and rabbit hemorrhagic disease. These diseases have caused significant reductions in rabbit populations on the Iberian Peninsula. Most studies have focused on the epidemiology and pathogenesis of these viruses individually, and little is known about interactions between these viruses and other parasites. Taking advantage of an experimental restocking program in Spain, the effects of coccidian and nematode infections on the probability of having detectable antibody to myxoma and rabbit hemorrhagic disease viruses were tested in European wild rabbits. For 14 mo, we monitored rabbit abundance and parasite loads (coccidia and nematodes) in three reintroduced rabbit populations. While coccidian and nematode loads explained seasonal antibody prevalences to myxoma virus, the pattern was less clear for rabbit hemorrhagic disease. Contrary to expectations, prevalence of antibody to myxoma virus was inversely proportional to coccidian load, while nematode load seemed to play a minor role. These results have implications for viral disease epidemiology and for disease management intended to increase rabbit populations in areas where they are important for ecosystem conservation.


Asunto(s)
Infecciones por Caliciviridae/veterinaria , Coccidiosis/veterinaria , Virus de la Enfermedad Hemorrágica del Conejo/inmunología , Myxoma virus/inmunología , Mixomatosis Infecciosa/inmunología , Infecciones por Nematodos/veterinaria , Conejos , Animales , Anticuerpos Antivirales/análisis , Anticuerpos Antivirales/inmunología , Infecciones por Caliciviridae/epidemiología , Infecciones por Caliciviridae/inmunología , Coccidiosis/epidemiología , Mixomatosis Infecciosa/epidemiología , Infecciones por Nematodos/epidemiología , Carga de Parásitos , Prevalencia , Conejos/inmunología , Conejos/parasitología , Conejos/virología
19.
Acta otorrinolaringol. esp ; 61(5): 371-374, sept.-oct. 2010. tab, graf
Artículo en Español | IBECS | ID: ibc-83118

RESUMEN

La manifestación de un linfoma no Hodgkin como tumor primario de la parótida representa el 5% de los tumores en esta localización. Se presentan 8 pacientes diagnosticados y tratados de linfoma no Hodgkin parotídeo en nuestro hospital entre 1996–2003. El 62% eran mujeres que presentaban una masa indurada de 4 meses de evolución. En todos los casos se realizó una punción aspiración con aguja fina y una tomografía computerizada siendo el estudio inmunohistoquímico esencial en el diagnóstico definitivo. Para ello, se realizó en todos los casos una biopsia. El tratamiento fue con quimioterapia en el 75% de los casos y en el 25% quirúrgico. El objetivo es analizar los patrones clínicos y patológicos, así como las distintas modalidades terapéuticas y pronósticas, que caracterizan a este tipo de patología basándonos en el análisis de nuestros pacientes y comparándolos con los reflejados en la literatura (AU)


The manifestation of non-Hodgkin lymphoma as a primary parotid tumour account for 5% of all tumours at this location. We present 8 patients diagnosed and treated for parotid non-Hodgkin lymphoma in our hospital between 1996 and 2003. Of the cases, 62% were women who had an indurated mass for almost 4 months. A fine needle aspiration and computed tomography were performed on all patients. The immunohistochemical study provided us with the definitive diagnosis. Biopsy was done in all cases. The treatment was chemotherapy in 75% cases and surgery in 25%.The objective was to analyse the clinical and pathological patterns, plus the different treatment modalities and prognoses, which characterise this type of pathology based on the analysis of our patients and compared with those reported in the literature (AU)


Asunto(s)
Humanos , Femenino , Masculino , Persona de Mediana Edad , Anciano , Linfoma no Hodgkin/tratamiento farmacológico , Neoplasias de la Parótida/tratamiento farmacológico , Linfoma no Hodgkin/diagnóstico , Neoplasias de la Parótida/diagnóstico , Estudios Retrospectivos , Biopsia con Aguja Fina , Inmunohistoquímica , Tomografía Computarizada por Rayos X
20.
Acta Otorrinolaringol Esp ; 61(5): 371-4, 2010.
Artículo en Español | MEDLINE | ID: mdl-20346432

RESUMEN

The manifestation of non-Hodgkin lymphoma as a primary parotid tumour account for 5% of all tumours at this location. We present 8 patients diagnosed and treated for parotid non-Hodgkin lymphoma in our hospital between 1996 and 2003. Of the cases, 62% were women who had an indurated mass for almost 4 months. A fine needle aspiration and computed tomography were performed on all patients. The immunohistochemical study provided us with the definitive diagnosis. Biopsy was done in all cases. The treatment was chemotherapy in 75% cases and surgery in 25%. The objective was to analyse the clinical and pathological patterns, plus the different treatment modalities and prognoses, which characterise this type of pathology based on the analysis of our patients and compared with those reported in the literature.


Asunto(s)
Linfoma no Hodgkin , Neoplasias de la Parótida , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Linfoma no Hodgkin/diagnóstico , Linfoma no Hodgkin/terapia , Masculino , Persona de Mediana Edad , Neoplasias de la Parótida/diagnóstico , Neoplasias de la Parótida/terapia
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